目的:观察比较分析急性百草枯中毒致药物性肝病的影响因素。方法:选择2008-01-2013-12入住我院急诊科的急性百草枯中毒患者112例,根据急性百草枯中毒致肝损伤的的诊断标准判断患者是否发生药物性肝病,分为损伤组和对照组,对患者性别、年龄、口服剂量、是否接受超早期洗胃治疗、是否接受早期血液灌流治疗、是否接受CRRT治疗等因素对百草枯所致药物性肝病的影响进行Logistic回归分析。结果:2组患者性别、年龄差异无统计学意义,Logistic回归分析发现口服剂量、是否接受超早期洗胃治疗、是否接受早期血液灌流治疗、是否接受CRRT治疗与急性百草枯患者肝损伤的发生可能存在相关性(P<0.05)。结论:百草枯的口服剂量对肝功能损伤的影响最大,及时给予超早期洗胃治疗、早期血液灌流治疗能减少患者肝功能损伤的发生。 Objective: To compare and analyze the influencing factors of drug-induced liver disease caused by acute paraquat poisoning. Methods: One hundred and twelve acute paraquat poisoning patients admitted to our emergency department from January 2008 to December 2013 were selected. According to the diagnostic criteria of acute liver injury caused by acute paraquat poisoning, the patients were divided into two groups: injury group and control group Group. Logistic regression analysis was performed on the factors such as sex, age, oral dose, whether to receive ultra-early gastric lavage, whether to receive early hemoperfusion, whether to accept CRRT and other factors on paraquat-induced drug-induced liver disease. Results: There was no significant difference in gender and age between the two groups. Logistic regression analysis showed that oral dose, ultra-early gastric lavage treatment, early hemoperfusion treatment, and whether or not CRRT treatment and acute paraquat liver injury were possible There was a correlation (P <0.05). Conclusion: Oral doses of paraquat have the greatest impact on liver function damage. Early gastric lavage treatment can be given in time. Early hemoperfusion treatment can reduce the occurrence of hepatic injury.