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目的:观察三白草提取物对肥胖Zucker大鼠血糖及胰岛素抵抗的影响。方法:6周龄雄性肥胖Zucker大鼠12只,适应性喂养2周后,随机分为对照组和三白草提取物组(350mg/kg),所有动物给予高脂饲料喂养,疗程为4周。每周检测体质量、随机血糖;入组前、第14、28d时检测口服葡萄糖耐量试验(OGTT)和空腹血清胰岛素水平;第28d时检测血脂4项和血浆游离脂肪酸(FFA);第29d时,进行高胰岛素正葡萄糖钳夹试验,观察平均葡萄糖输注率(GIR)。结果:与对照组相比,治疗4周后,三白草提取物血清胰岛素轻度降低、高胰岛素正葡萄糖钳夹试验后GIR轻度升高;随机血糖、FFA均显著下降;体质量、进食量、OGTT有下降的趋势;对血脂无影响。结论:三白草提取物能轻度改善胰岛素抵抗。
Objective: To observe the effect of Saururus chinensis extract on blood glucose and insulin resistance in obese Zucker rats. Methods: Twelve male Zucker rats, 6 weeks old, were randomly divided into control group and Siberian herb extract group (350mg / kg) after 2 weeks of adaptive feeding. All animals were given high fat diet for 4 weeks . Body mass and random blood sugar were measured every week. OGTT and fasting serum insulin levels were measured before the 14th and 28th day before admission, 4th grade and FFA were measured on the 28th day, , High-insulin positive glucose clamp test, observe the average glucose infusion rate (GIR). Results: Compared with the control group, after 4 weeks of treatment, the serum insulin of Sanguisca grass extract decreased slightly and the GIR slightly increased after hyperinsulinemic positive glucose clamp test; the levels of random blood glucose and FFA decreased significantly; the body weight, Volume, OGTT have a downward trend; no effect on blood lipids. Conclusion: Saururus chinensis extract can slightly improve insulin resistance.