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目的:探讨枳实挥发油对慢传输型便秘(STC)大鼠的治疗作用及可能的作用机理。方法:应用盐酸吗啡制作STC模型大鼠,采用活性炭悬液推进法测定枳实挥发油干预前后大鼠肠道推进功能,并采用在体结肠肌电测定法测定枳实挥发油干预前后大鼠结肠的肌电活动情况。结果:与模型对照组相比,枳实挥发油组STC大鼠肠道推进率增加(26.33±7.71%vs 19.74±3.94%,P<0.05),结肠慢波振幅减小、频率加快(0.35±0.05vs 0.43±0.05,8.38±0.96 vs 6.02±1.10,P<0.05),振幅及频率变异系数均减小(11.07±1.21 vs 12.27±1.51,16.35±3.25 vs 23.43±3.02,P<0.05)。结论:枳实挥发油可增强STC结肠推进功能,其治疗作用机制之一是纠正STC异常的结肠慢波,为其用于STC的治疗提供了一定的实验学参考。
Objective: To investigate the therapeutic effect and possible mechanism of volatile oil of Fructus Aurantii Immaturus on rats with slow transit constipation (STC). Methods: STC model rats were made by morphine hydrochloride. The intestinal propulsive function of volatile oil of Fructus Aurantii Immaturus before and after the intervention of volatile oil of Fructus Aurantii Immaturus was determined by activated carbon suspension propulsion method. The colonic muscle of rats were measured before and after the intervention of essential oil of Fructus Aurantii Electrical activity. Results: Compared with the model control group, the intestinal propulsion rate of STZ-treated rats increased significantly (26.33 ± 7.71% vs 19.74 ± 3.94%, P <0.05) vs 0.43 ± 0.05,8.38 ± 0.96 vs 6.02 ± 1.10, P <0.05). The coefficients of variation of amplitude and frequency were all decreased (11.07 ± 1.21 vs 12.27 ± 1.51, 16.35 ± 3.25 vs 23.43 ± 3.02, P <0.05). CONCLUSION: Volatile oil of Fructus Aurantii Immaturus can enhance colonic propulsion of STC. One of its therapeutic mechanisms is to correct the abnormal CSC in STC. It provides some experimental references for the treatment of STC.