论文部分内容阅读
目的:本研究探讨复方丹参滴丸一次和多次预给药对缺血再灌注引起的大鼠心脏微循环障碍和心肌伤的保护作用。方法:雄性SD大鼠,结扎心脏冠状动脉前降支,30min后解除结扎,建立心脏缺血再灌注型。假手术组仅穿线不结扎。一次预给药组在缺血再灌注前90min灌胃给予复方丹参滴丸(剂量0
Objective: This study was to investigate the protective effects of Fufang Danshen Diwan once and several times on ischemia-reperfusion-induced cardiac microcirculation and myocardial injury in rats. Methods: Male Sprague - Dawley rats were ligated with anterior descending coronary artery and ligated after 30 min to establish a model of cardiac ischemia - reperfusion. Sham operation group only threading not ligation. In the once premedication group, Fufang Danshen dripping pills were administered intragastrically for 90 min before ischemia-reperfusion (dose 0)