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目的:探讨低剂量长、短效达菲林在控制性超促排卵中的垂体降调效果及临床结局。方法:选择IVF-ET患者206例,均于前一月经周期黄体中期开始注射达菲林。随机分为3组,A组:n=100,长效达菲林1.25 mg;B组:n=56例,注射短效达菲林0.05 mg/d,至hCG日;C组:n=50,注射短效达菲林0.1 mg/d,至Gn日改为0.1 mg/次,qod至hCG日。结果:①Gn使用天数及用量:A组(11.6±2.5 d,2591.2±287.2 IU)显著多于B组(10.1±2.6 d,2198.6±383.4 IU)和C组(10.4±2.2 d,2 156±306.4 IU)(P<0.05)。②降调后Gn启动日血清LH值:A组为1.23±0.25 IU/L,B组为2.9±0.37 IU/L,C组为2.39±0.54 IU/L,A组显著低于C组,C组显著低于B组(P均<0.01)。③hCG注射日LH值:A组(1.48±0.12 IU/L)显著低于B组(2.50±0.34 IU/L)和C组(2.90±0.90 IU/L)(P<0.01)。④获卵数、成熟卵子数、优质胚胎数及临床妊娠率A组均明显高于B组和C组(P<0.01)。结论:长效达菲林1.25 mg垂体降调效果及临床结局均优于短效达菲林组。
Objective: To investigate the hypopituitarism effect and clinical outcome of low and long-acting daphnilin in controlled ovarian hyperstimulation. Methods: A total of 206 patients with IVF-ET were enrolled in the study. All patients were given dafenil at the mid-luteal phase of the previous menstrual cycle. Randomly divided into three groups, group A: n = 100, long-acting dipyridamole 1.25 mg; group B: n = 56, injection of short-acting Tamiflu 0.05 mg / d to hCG; Short-term Tamiflune 0.1 mg / d, to Gn day changed to 0.1 mg / time, qod to hCG day. Results: ① The days and dosage of Gn were significantly higher in group A (11.6 ± 2.5 d, 2591.2 ± 287.2 IU) than in group B (10.1 ± 2.6 d, 2198.6 ± 383.4 IU) and group C (10.4 ± 2.2 d, 2 156 ± 306.4 IU) (P <0.05). ② Serum LH of Gn on day after down-regulation: 1.23 ± 0.25 IU / L in group A, 2.9 ± 0.37 IU / L in group B, 2.39 ± 0.54 IU / L in group C, significantly lower in group A than in group C Group was significantly lower than the B group (P all <0.01). ③ LH value on the day of HCG injection was significantly lower in group A (1.48 ± 0.12 IU / L) than in group B (2.50 ± 0.34 IU / L) and group C (2.90 ± 0.90 IU / L) (P <0.01). ④ The number of oocytes, number of mature eggs, number of high quality embryos and clinical pregnancy rate in group A were significantly higher than those in group B and C (P <0.01). Conclusion: Long-acting diphenhydramine 1.25 mg pituitary down-regulation effect and clinical outcome are better than short-term Tamiflu group.