The need for mutational analysis in myeloid neoplasms,Some (well-known) technical issues specific to NGS Variant analysis&interpretation,What happens if one encounters a presumptive germline variant during a‘somaticanalysis,Personal thoughts on a possible Way forward.NGS-based clinical assays come with unique challenges.Interlaboratory reproducibility is critical, if anything to avoid potential medicolegally unpleasant outcomes.Technical reproducibility, particularly if different platforms are utilized.Interpretative reproducibility.