论文部分内容阅读
本文对云南产药用植物风吹楠(Horsfieldia glabra)开展了化学成分的研究。共分离得到51个化合物,其中有7个新化合物。利用各种柱层析技术和波谱解析,从风吹楠的树干及枝叶中分离鉴定了51个化合物,包括1,3-二芳基丙烷、倍半萜、开链二萜、三萜、黄烷、查尔酮、黄酮、黄酮苷、二氢黄酮、芳基酮、简单芳香族、木脂素和甾体等类型,结构分别为:(2R,4R)-4′-hydroxy-3′,5′-methyl-6,7-methylenedioxy-4-O-2′-cycloflavan(1),(2R,4R)-4′-hydroxy-3′-methyl-6,7-methylenedioxy-4-O-2′-cycloflavan(2),(-)-catechin(3),(-)-epicatechin(4),(-)-festidinol(5),naringenin(6),(-)-butin(7),(-)-eriodictyol(8),liquiritigenin(9),quercetin(10),morin(11),sulfuretin(12),4,2′-dihydroxy-4′-methoxychalcone(13),(3R)-vestitone(14),quercetin-3-O-β-D-glucoside(15),morin-3-O-α-rhamnopyranoside(16),kaempferol-3-O-α-L-rhamnopyranoside(17),quercetin-3-O-α-L-rhamnopyranoside(18),hemipholin[(+)-6-C-β-D-glucopyranosyl(2S)naringenin](19),1-(2′,4′-dihydroxyphenyl)-3-(2′′-hydroxy-4′′,5′′-methylenedioxyphenyl)-propane(20),1-(2′-hydroxy-4′′,5′′-methoxylphenyl)-3-(3′′,4′′-methylenedioxyphenyl)-propane(21),1-(2′,4′-dihydroxy-3′-methylphenyl)-3-(2′′-hydroxy-4′′,5′′-methylenedioxyphenyl)-propane(22),virolane(23),1-(4′-hydroxy-2′-methoxyphenyl)-3-(4′′-hydroxy-3′′-methoxyphenyl)-propane(24),1-(2′,4′-dihydroxyphenyl)-3-(3′′,4′′-methylenedioxyphenyl)-propane(25),1-(2′,4′-hydroxy-3′,5′-dimethylphenyl)-3-(2′′-hydroxy-4′′,5′′-methylenedioxyphenyl)-propane(26),1-(2′,4′-dihydroxyphenyl)-3-(2′′-methoxy-4′′,5′′-methylenedioxyphenyl)-propane(27),bauhiniasin(28),euonyphenylpropane A(29),horsfiebra A(30),horsfiebra B(31),myristinin G(32),myristicyclin A(33),betulinic acid(34),(-)-(3R)-18-hydroxygeranyllinalool(35),plaunotol(36),4(14)-eudesmene-6α,11-diol(37),(-)-clovane-2,9-diol(38),(-)-caryolane-1,9β-diol(39),vomifoliol(40),(-)-sesamin(41),(-)-kobusin(42),(+)-piperitol(43),(-)-eudesmin(44),demethylpiperitol(45),isocubebin(46),dodecanoylphloroglucinol(47),1-(2,6-dihydroxyphenyl)-4-methyl-4-tridecen-1-one(48),3,6-dihydroxy-2-[1-oxo-9(Z)-octadecenyl]-cyclohex-2-en-1-one(49),3,4-dihydroxybenzoic acid(50),β-sitosterol(51)。其中化合物1-2,20,30-32,35为新化合物,化合物6-8,10-11,14-19,24,26-29,34,36-40,42,44-46为首次从该属植物中分离得到。除了化合物48,其它均为从风吹楠植物中首次得到。对风吹楠中分离得到的化合物1-2,20,23,31,34-35,42-43,47进行了细胞毒活性的筛选。其中,化合物31对五株癌细胞A-549,HL-60,SMMC-7721,SW-480,MCF-7表现出一定的细胞毒活性,其IC50值分别为18.58μM,20.76μM,13.92μM,18.12μM,12.92μM,其它的化合物显示没有明显的体外细胞毒活性。最后,综述部分归纳了植物中1,3-二芳基丙烷类型的化合物及其生物活性研究进展。