N-三甲基壳聚糖包衣去氢骆驼蓬碱脂质体制备及其在大鼠体内药物代谢动力学

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目的:(1)筛选最优处方,制备去氢骆驼蓬碱(HM)脂质体(HM-lip),以N-三甲基壳聚糖(TMC)对其进行包衣制备TMC包衣的HM-lip(TMC-HM-lip),并考察HM、HM-lip和TMC-HM-lip的体外释放情况。(2)制备含有不同冻干保护剂的N-三甲基壳聚糖(TMC)包衣去氢骆驼蓬碱脂质体(TMC-HM-Lip)冻干粉,并筛选出最佳制备工艺。(3)以尾静脉注射和灌胃两种给药方式,探讨HM、HM-lip和TMC-HM-lip在大鼠体内的药代动力学。方法:(1)通过薄膜分散-p
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