Objectives:The study exploredanapplicable nursing intervention modeandcomprehensive nursing intervention measures on family treatmentand nursing for childrenwith hemophiliaAand their parents,and examined the effect of comprehensive nursingintervention.　　Methods:Aself-control,quasi-experimental study was conducted withaconvenientsample of52children with hemophiliaAand their parents discussedand summarized theproblems in family treatmentand nursing for children with hemophiliaso to developcomprehensive nursing intervention measures including individualized coagulation factorsinjection training course,hemophiliahealth education programs,children hemophiliafamilies sodalityand follow-up visiting of the family treatmentand nursing behaviorsthrough literature reviewand expert consultation.Datawere collected using structuredquestionnairesand MPOC-56scale from January,2012to March,2013.Chi-Square testand Paired-Samples T test were utilized for dataanalyses.　　Results:　　1.After intervention,among22items of family treatmentand nursing behaviors,19itemswere significantly improved compared with that before intervention(X2=59,88,36,47,96,30,13,57,34,67,55.06,55.06,55.06,21.85,22.69,45.69,39.33,68.25,11.99,35.39,35.39,17.24,81.51,85.75,13.57,respectively;P<0.01).The incidence of"correctlyrecord every bleedingand treatment"among the patient was2cases(3.85％)beforeintervention,while that was48cases(92.31％)after intervention.The incidence of"monthly report the bleedingand therapy nursing information to nurses"was raised from5cases(20％)before intervention to52cases(100％)after intervention,and the differencewas statistically significant(X2=81.51,85.75,respectively;P