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目的探讨抗神经元突触囊泡Ａｍｐｈｉｐｈｙｓｉｎ抗体（抗Ａｍｐｈｉｐｈｙｓｉｎ抗体）在神经系统副肿瘤综合征（ＰＮＳＮＳ）发病机制中的作用及与癌肿的关系。方法应用免疫印迹技术测定３９０例小细胞肺癌（ＳＣＬＣ）１０３例其他癌肿及１０４例非ＰＮＳＮＳ的神经系统疾病患者血清中抗Ａｍｐｈｉｐｈｙｓｉｎ抗体。结果１１例ＳＣＬＣ患者血清中存在抗Ａｍｐｈｉｐｈｙｓｉｎ抗体，其中８例伴有ＰＮＳＮＳ。抗Ａｍｐｈｉｐｈｙｓｉｎ抗体识别脑神经元提取物中抗原相对分子量分子量１２５万的蛋白带。结论抗Ａｍｐｈｉｐｈｙｓｉｎ抗体是一种与ＰＮＳＮＳ及ＳＣＬＣ有关的神经元自身抗体，检测此种抗体对于ＰＮＳＮＳ及ＳＣＬＣ的临床诊断及治疗有一定的意义
Objective To investigate the role of anti-neuronal synaptic vesicle Amphiphysin antibody (anti-Amphiphysin antibody) in the pathogenesis of paraneoplastic syndrome of the nervous system (PNSNS) and its relationship with cancer. METHODS: Immunoblotting was used to detect anti-Amphiphysin antibodies in 390 cases of small cell lung cancer (SCLC), 103 cases of other cancers, and 104 cases of non-PNSNS neurological disease. Results There were anti-Amphiphysin antibodies in the serum of 11 patients with SCLC, 8 of which were associated with PNSNS. The anti-Amphiphin antibody recognizes the protein band with an antigen molecular weight of 12 to 50 thousand in brain neuron extracts. Conclusion Anti-Amphiphin antibody is a kind of neuron autoantibody related to PNSNS and SCLC. Detection of this antibody has certain significance for the clinical diagnosis and treatment of PNSNS and SCLC.