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核因子Kappa B(Nuclear factor Kappa B,NF-κB)是一种广泛存在于哺乳动物细胞中的转录因子,近年来越来越多的证据表明,它与脑出血后的继发性脑损伤的关系密切。本文从NF-κB的生物学特性出发阐述了NF-κB信号通路在脑出血后继发性脑损伤中的作用及其机制,包括:促进炎性因子IL-1β、ICAM-1等的表达,引发和加重炎症反应;上调MMP-9的表达,破坏血脑屏障,加重血管源性脑水肿;促进细胞凋亡的发生。
Nuclear factor Kappa B (NF-κB) is a transcription factor widely found in mammalian cells. In recent years, there is more and more evidence that it is associated with secondary brain injury after cerebral hemorrhage Close relationship. Based on the biological characteristics of NF-κB, this article describes the role of NF-κB signaling in secondary brain injury following intracerebral hemorrhage and its mechanisms, including: promoting the expression of inflammatory factors such as IL-1β and ICAM-1 And aggravate the inflammatory response; up-regulate the expression of MMP-9, destroy the blood-brain barrier, aggravate vasogenic brain edema and promote the occurrence of apoptosis.