输液配伍变化值得注意,尤其是静脉营养输液比一般输液成分复杂、滴注时间较长,配伍后的经时变化更值得研究。本文报道,用高压液相色谱法(HPLC),对输液中常用的AsA及FAD进行定量分析,考察其稳定性,并分析静脉滴注过程中配伍的AsA、FAD稳定性的变化情况。本法简便迅速,具有实用价值。层析条件实验用岛津LC-3A型高压液相色谱仪,附岛津C-RIA数据处理机,紫外检测器及荧光检测器;层析柱为Shodex ohpak M-614,φ6×250nm:流动相为0.01 MKH_2PO_4-0.01MK_2HPO_4缓冲液;流速0.5ml/min。 Changes in infusion compatibility is noteworthy, especially intravenous infusion of fluid infusion components in general more complex, longer infusion time, compatibility changes over time more worthy of study. This paper reports the quantitative analysis of AsA and FAD, commonly used in infusion, by HPLC to investigate the stability of AsA and FAD during the intravenous drip. This law is quick and easy, with practical value. Chromatographic conditions were measured using a Shimadzu LC-3A high-pressure liquid chromatograph, a Shimadzu C-RIA data processor, a UV detector and a fluorescence detector; the column was Shodex ohpak M-614, φ6 × 250 nm: flow Phase 0.01 MKH_2PO_4-0.01MK_2HPO_4 buffer; flow rate 0.5ml / min.