目的进一步了解新型抗精神病药物不良反应及应对策略。方法以我院2007年6月至2008年6月期间应用新型抗精神病药物出现不良反应而换药的23例精神疾病患者为研究对象,对出现的不良反应进行归类分析。结果应用利培酮出现不良反应换药的13例,其中锥体外系反应4例,闭经6例,体质量增加3例;应用奥氮平出现不良反应换药的8例,其中血糖升高3例,甘油三酯升高2例,体质量增加3例;应用硫奎平出现不良反应换药的2例,其中体质量增加1例,血糖升高1例。结论新型抗精神病药物的不良反应不容忽视,特别是对体质量、糖脂代谢的影响,在应用时应注意监测体质量、血糖、血脂的变化,以便优化精神障碍患者的预后。 Objective To further understand the new antipsychotic adverse reactions and coping strategies. Methods From June 2007 to June 2008 in our hospital, the patients with mental illness who applied new antipsychotics adverse reactions to dressing were enrolled in this study. The adverse reactions were classified and analyzed. Results Risperidone application of adverse reactions dressing in 13 cases, including extrapyramidal reaction in 4 cases, amenorrhea in 6 cases, body mass increased in 3 cases; the application of olanzapine adverse reactions dressing in 8 cases, including elevated blood glucose 3 Cases, two cases of elevated triglycerides, body mass increased in three cases; the application of sulfuretin adverse reactions in 2 cases, of which 1 case of body mass gain, 1 case of elevated blood sugar. Conclusion The adverse reactions of the new antipsychotics can not be ignored, especially on the body weight and the metabolism of glucose and lipid. At the time of application, we should pay attention to monitoring the changes of body weight, blood glucose and blood lipids in order to optimize the prognosis of patients with mental disorders.