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最新研究表明,超量运动中Th2细胞因子IL-4I、L-6I、L-10及TNF-α水平的明显上调及应激激素的大量分泌,造成Th1和Th2之比失衡,进而导致体液免疫功能增强、细胞免疫功能相对低下,是继慢性运动后感染性疾病发病率增高的主要原因。而运动应激以及运动中损伤则是免疫系统应答的激活因子。诱导性协同刺激分子在运动后活化T细胞上的表达及其对Th2细胞的分化诱导,表明了它在运动免疫应答中重要而独特的作用。
Recent studies show that over-excretion of Th2 cytokines IL-4I, L-6I, L-10 and TNF-α levels were significantly increased and the secretion of a large number of stress hormones, resulting in Th1 and Th2 imbalance, which led to humoral immunity Function enhancement, relatively low cellular immune function, is the main reason for the increased incidence of infectious diseases after chronic exercise. However, exercise stress and injury during exercise are the activation factors of immune system response. The expression of inducible costimulatory molecules on activated T cells after exercise and their induction of differentiation into Th2 cells suggest that it plays an important and unique role in motor immune response.