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[目的]探讨核黄素强化盐干预试验对人群肿瘤发病率的影响。[方法]对盐亭县核黄素强化盐干预试验人群干预期(1992～1996)和干预停止期(1997～2001)的肿瘤发病资料进行分析。[结果]试验组男性食管癌、肺癌、结直肠癌,女性食管癌、白血病、宫颈癌发病率在干预期高于对照组,而在干预停止期低于对照组。两组人群10年的肿瘤发病资料比较,试验组除胃癌外其他肿瘤发病率均低于对照组,尤其是食管癌和宫颈癌发病率明显低于对照组,而两组人群中肺癌、结直肠癌发病率都上升,但试验组的上升幅度低于对照组。[结论]试验组与对照组肿瘤发病率的差异,提示补充核黄素有利于降低肿瘤的发病风险,值得在更大范围的肿瘤高危人群中推广。
[Objective] To investigate the effect of riboflavin enhanced salt intervention on the incidence of cancer in the population. [Method] The incidence of tumor in intervention period (1992 ~ 1996) and intervention cessation period (1997 ~ 2001) in the experimental group of intervention of riboflavin in Yanting County was analyzed. [Results] The incidence of esophageal cancer, lung cancer, colorectal cancer, esophageal cancer, leukemia and cervical cancer in the experimental group was higher than that in the control group in the intervention period and lower than that in the control group in the stop period of the intervention. Two groups of patients with 10-year tumor incidence data comparison, the experimental group except gastric cancer incidence of other tumors were lower than the control group, especially the incidence of esophageal cancer and cervical cancer was significantly lower than the control group, while two groups of lung cancer, colorectal Cancer incidence increased, but the test group increased less than the control group. [Conclusion] The difference of tumor incidence between the experimental group and the control group suggests that riboflavin supplementation can reduce the risk of developing tumors and is worth popularizing in a wider range of cancer-at-risk populations.