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目的 观察早期应用纳络酮对急性重型脑出血预后的影响。方法 将 90例急性重症脑出血病人随机分为对照组 (n =45)和纳络酮组 (n =45)。观察治疗期间病人生命体征、颅内压和远期疗效 ,并进行统计学分析。结果 纳络酮组病人呼吸异常、心律异常明显减少 (P <0 0 1 ) ,清醒时间明显缩短 (P <0 0 1 )。 1周后颅内压显著升高者明显减少 (2 2 2 % ,P <0 0 1 ) ,3个月后治愈率明显增高 (61 8% ,P <0 0 1 )。结论 早期采用纳络酮治疗急性重症脑出血 ,可以降低颅内压 ,减轻脑水肿 ,缩短昏迷时间 ,促进神经功能恢复
Objective To observe the effect of early application of naloxone on the prognosis of acute severe intracerebral hemorrhage. Methods Ninety patients with acute severe intracerebral hemorrhage were randomly divided into control group (n = 45) and naloxone group (n = 45). During the treatment of patients with vital signs, intracranial pressure and long-term efficacy, and statistical analysis. Results Patients in naloxone group had abnormal respiratory rate, abnormal heart rhythm (P <0.01) and significantly shorter awake time (P <0.01). After 1 week, the significant increase of intracranial pressure was significantly reduced (22.2%, P <0.01). After 3 months, the cure rate was significantly higher (61.8%, P <0.01). Conclusion Naloxone treatment of acute severe intracerebral hemorrhage early can reduce intracranial pressure, reduce cerebral edema, shorten the coma time and promote neurological recovery