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目的探讨增加异烟肼用药剂量对结核病初治疗效的影响。方法选取本溪市第六人民医院2015年1月—2016年1月收治的结核病初治患者60例,随机分为对照组和研究组,各30例。对照组患者予以常规药物治疗,研究组患者在对照组治疗基础上增加异烟肼使用剂量。两组患者治疗后随访1年,比较两组患者痰涂片、痰培养转阴率和肝功能损伤发生率,临床疗效及复发率。结果研究组患者痰涂片和痰培养转阴率高于对照组,肝功能损伤发生率低于对照组(P<0.05)。研究组患者临床疗效优于对照组(P<0.05)。研究组复发率低于对照组(P<0.05)。结论在结核病初治治疗中,适当提高异烟肼用药剂量可提高结核病患者痰菌转阴率和治愈率,减少肝功能损伤和结核病复发率。
Objective To explore the effect of increasing dose of isoniazid on the initial treatment of tuberculosis. Methods Sixty patients with newly diagnosed tuberculosis admitted to the Sixth People’s Hospital of Benxi from January 2015 to January 2016 were randomly divided into control group and study group, with 30 cases in each group. Patients in the control group were treated with conventional drugs. Patients in the study group were given isoniazid at a dose that was increased based on the control group. Two groups of patients were followed up for 1 year after treatment. The sputum smear, the negative conversion rate of sputum culture, the incidence of hepatic injury, clinical efficacy and recurrence rate were compared between the two groups. Results The sputum smear and sputum culture negative rate in study group was higher than that in control group, and the incidence of hepatic injury was lower than that in control group (P <0.05). The clinical efficacy of the study group was better than that of the control group (P <0.05). The recurrence rate of the study group was lower than that of the control group (P <0.05). Conclusions In the initial treatment of tuberculosis, the appropriate dose of isoniazid can increase the negative rate and cure rate of sputum bacterium in TB patients and reduce the rate of liver function damage and tuberculosis recurrence.