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通过高分辨质谱(分辨率70000)对人体尿液中常见5种毒品进行快速筛查测定,避免了复杂的前处理过程,通过比较其保留时间、质荷比、以及同位素丰度比,不需要对其进行二级扫描,即可进行准确的定性、定量分析。结果表明,5种毒品在0.5~20 ng/m L范围内线性关系良好,相关系数R2大于0.995,定量限为1.0μg/kg,回收率范围83.7%~101.5%;相对标准偏差小于10%。方法可用于尿液样品中常见毒品的快速确证检测。
Rapid screening of five common drugs in human urine by high resolution mass spectrometry (resolution 70000) eliminates the need for complex pre-treatment processes by comparing their retention time, mass-to-charge ratio, and isotope abundance ratio The second-level scanning, you can carry out accurate qualitative and quantitative analysis. The results showed that the five drugs showed a good linearity in the range of 0.5-20 ng / m L with a correlation coefficient of R2 greater than 0.995 and a limit of quantification of 1.0 μg / kg. The recoveries ranged from 83.7% to 101.5%. The relative standard deviations were less than 10%. The method can be used for the rapid confirmation test of common drugs in urine samples.