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目的 :观察人胎盘提取液对高脂鼠脂蛋白 -胆固醇代谢及血小板聚集功能的影响。方法 :Wistar大鼠定量给予高脂饲料建立高脂模型 ,用胎盘提取液 4ml/(kg· d)连续灌胃 1 2 d,测定血脂 ,脂蛋白 ;血浆中前列环素 (PGI2 ) ,血栓素 A2 (Tx A2 )含量及血小板最大聚集率 (MA)。结果 :胎盘提取液可使高脂鼠血清中高密度脂蛋白明显升高 ,甘油三酯、胆固醇、低密度脂蛋白含量明显降低 (P <0 .0 1 ) ;使血浆中前列环素含量明显升高 (P <0 .0 1 ) ,Tx A2 含量无明显变化 ,并明显降低 MA(P <0 .0 1 )。结论 :胎盘提取液通过改善脂蛋白 -胆固醇代谢及抑制血小板聚集的综合效应拮抗动脉粥样硬化的发生和发展
Objective: To observe the effects of human placental extract on lipoprotein-cholesterol metabolism and platelet aggregation in high-fat mice. METHODS: Wistar rats were given a high-fat diet to establish a high-fat model. Placenta extract was continuously administered at a dose of 4 ml/(kg·d) for 12 days to determine blood lipids and lipoproteins; plasma prostacyclin (PGI2) and thromboxanes. A2 (Tx A2) content and platelet maximum aggregation rate (MA). RESULTS: Placenta extract could significantly increase high-density lipoprotein (HDL) in serum of hyperlipidemic rats, and significantly decreased triglyceride, cholesterol, and low-density lipoprotein levels (P < 0.01); significantly increased plasma prostacyclin levels. High (P <0. 01), Tx A2 content did not change significantly, and significantly reduced MA (P <0. 0 1). Conclusion: Placenta extract antagonizes the occurrence and development of atherosclerosis by improving the combined effects of lipoprotein-cholesterol metabolism and inhibition of platelet aggregation.