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目的评价艾滋病抗病毒治疗(ART)的临床疗效,探讨少数民族地区ART经验。方法采用回顾性方法,分析2005年7月-2011年6月期间,初次接受ART的506例艾滋病病人的临床资料和CD4+T淋巴细胞计数。结果 506例病人均为彝族农民,多为男性,文盲,有饮酒习惯,HBsAg阳性率26.9%,抗丙型肝炎病毒(HCV)抗体阳性率20.8%,CD4+T淋巴细胞均值在基线、治疗6个月和12个月时分别为231个/μL、324个/μL和390个/μL。治疗免疫学失败率在6个月和12个月时,分别为21.9%和25.6%;免疫学成功组服药依从性为96.0%,失败组依从性为16.4%,两者差异有统计学意义。结论在少数民族地区应及时推广ART,努力提高依从性,减少免疫学失败。
Objective To evaluate the clinical effect of ART on AIDS and to explore ART experience in ethnic minority areas. Methods A retrospective analysis was conducted to analyze the clinical data and CD4 + T lymphocyte counts of 506 AIDS patients who received ART for the first time between July 2005 and June 2011. Results All 506 patients were Yi peasants, mostly male, illiterate, with drinking habits. The positive rate of HBsAg was 26.9% and the positive rate of anti-HCV antibody was 20.8%. The mean CD4 + T lymphocyte count was at baseline and 6 231 / μL, 324 / μL, and 390 / μL for the month and 12 months, respectively. The immunological failure rates were 21.9% and 25.6% at 6 months and 12 months, respectively. The compliance rate in the immunological success group was 96.0% and in the failed group was 16.4%. The difference was statistically significant. Conclusion ART should be popularized in ethnic minority areas in an effort to improve compliance and reduce immunological failure.