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目的:探讨横纹肌样未分化癌的临床病理特征、免疫表型及鉴别诊断。方法:对2例横纹肌样未分化癌进行分析并复习相关文献,观察其组织学形态及免疫组化标记结果。结果:2例肿瘤分别位于小肠和直肠,均呈浸润性生长,2例肿瘤组织学形态相似,肿瘤细胞异型明显,核大核仁明显,胞浆丰富,嗜酸性,细胞呈上皮样或横纹肌样,细胞间黏附性差。免疫组化,两例肿瘤细胞均表达vimentin,CK,INI1和EMA。结论:横纹肌样未分化癌是一种罕见类型肿瘤,具有高度侵袭性,预后差。对该肿瘤确诊主要依靠组织学形态和免疫组化标记,需要与其他恶性肿瘤进行鉴别。
Objective: To investigate the clinicopathological features, immunophenotype and differential diagnosis of rhabdomyosarcoma undifferentiated carcinoma. Methods: Two cases of rhabdomyosarcoma undifferentiated carcinoma were analyzed and the related literatures were reviewed. The histological morphology and immunohistochemical results were observed. Results: The two tumors were located in the small intestine and rectum, all showed infiltrative growth. The histological morphology of the two tumors were similar. The tumor cells were abnormally shaped. The nuclei showed obvious nucleoli, abundant cytoplasm, eosinophilicity, epithelial or rhabdomyosarcoma , Poor adhesion between cells. Immunohistochemistry showed that both tumor cells expressed vimentin, CK, INI1 and EMA. Conclusions: Rhabdomyosarcoma undifferentiated carcinoma is a rare type of tumor that is highly invasive and has a poor prognosis. The diagnosis of the tumor depends mainly on histological morphology and immunohistochemical markers, need to identify with other malignancies.