Purpose:5.12 Wenchuan earthquake and 4.25 Nepal earthquake are of the similar magnitude,but the climate and geographic environment are totally different.Our team carried out medical rescue in both disasters,so we would like to compare the different traumatic conditions of the wounded in two earthquakes.Methods:The clinical data of the wounded respectively in 5.12 Wenchuan earthquake and 4.25 Nepal earthquake rescued by Chengdu Military General Hospital were retrospectively analyzed.Then a contrast study between the wounded was conducted in terms of age,sex,injury mechanisms,traumatic conditions,complications and prognosis.Results:Three days after 5.12 Wenchuan earthquake,465 cases of the wounded were hospitalized in Chengdu Military General Hospital,including 245 males (52.7％) and 220 females (47.3％) with the average age of (47.6 ± 22.7) years.Our team carried out humanitarian relief in Katmandu after 4.25 Nepal earthquake.Three days after this disaster,71 cases were treated in our field hospital,including 37 males (52.1％) and 34 females (47.9％) with the mean age of (44.8 ± 22.9) years.There was no obvious difference in sex and mean age between two groups,but the age distribution was a little different:there were more wounded people at the age over 60 years in 4.25 Nepal earthquake (p ＜ 0.01) while more wounded people at the age between 21 and 60 years in 5.12 Wenchuan earthquake (p ＜ 0.05).The main cause of injury in both disasters was bruise by heavy drops but 5.12 Wenchuan earthquake had a higher rate of bruise injury and crush injury (p ＜ 0.05) while 4.25 Nepal earthquake had a higher rate of falling injury (p ＜ 0.01).Limb fracture was the most common injury type in both disasters.However,compared with 5.12 Wenchuan earthquake,4.25 Nepal earthquake has a much higher incidence of limb fractures (p ＜ 0.01),lung infection (p ＜ 0.01) and malnutrition (p ＜ 0.05),but a lower incidence of thoracic injury (p ＜ 0.05) and multiple injury (p ＜ 0.05).The other complications and death rate showed no significant differences.Conclusion:Major earthquakes of the similar magnitude can cause different injury mechanisms,traumatic conditions and complications in the wounded under different climate and geographic environment.When an earthquake occurs in a poor traffic area of high altitude and large temperature difference,early medical rescue,injury control and wounded evacuation as well as sufficient warmth retention and food supply are of vital significance.