论文部分内容阅读
目的:观察阿托品联合东莨菪碱交替使用治疗重度急性有机磷中毒(AOPP)的疗效和临床价值。方法:124例重度AOPP患者在常规治疗的基础上,在拮抗胆碱作用方面随机以阿托品(对照组)单独使用或以阿托品联合东莨菪碱(治疗组)交替使用,观察两组昏迷患者的平均恢复清醒时间、阿托品化时间、达托品化所需阿托品用量、阿托品总量、阿托品中毒发生率、中间综合征(IMS)发生率、阿托品依赖发生率及死亡率。结果:治疗组昏迷患者的平均恢复清醒时间缩短,阿托品化时间缩短及所需阿托品量减少,阿托品总量明显减少,阿托品中毒发生率下降,IMS发生率下降,阿托品依赖发生率下降,死亡率明显下降。结论:以阿托品联合东莨菪碱交替应用抢救重度AOPP,使实际阿托品的需要量减少,有利于避免阿托品过量所产生的不良现象,提高抢救成功率。
Objective: To observe the curative effect and clinical value of atropine combined with scopolamine in the treatment of severe acute organophosphorus poisoning (AOPP). Methods: One hundred and twenty-four patients with severe AOPP were randomly divided into atropine (control group) and atropine combined with scopolamine (treatment group) on the basis of routine treatment. The average recovery was observed in both coma patients Time, atropisation time, amount of atropine required for Dart Tartarization, total amount of atropine, incidence of atropine poisoning, incidence of intermediate syndrome (IMS), atropine dependence and mortality. Results: The recovery time of coma in patients in treatment group was shortened, the time of atropisation and the required atropine decreased, the total amount of atropine decreased, the incidence of atropine poisoning decreased, the incidence of IMS decreased, the incidence of atropine dependence decreased, and the mortality rate was significantly lower decline. Conclusion: Atropine combined with scopolamine alternate rescue salvage AOPP, so that the actual need for atropine decreased, help to avoid the adverse effects of atropine overdose, and improve the success rate of rescue.