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目的探讨尿液p H与代谢综合征(Met S)的关系。方法以8 720名在山东大学附属省立医院健康查体中心健康体检者建立纵向队列,使用Cox比例风险模型探讨尿液p H与Met S的关系。结果经过平均3.03年随访共有1 657人发生Met S,发病密度为62.79/1 000(1 657/26 389)人·年。仅对年龄进行调整时尿液p H偏低组的风险比HR值为1.36(95%CI:1.21~1.53,P<0.05),在此基础上对Met S的组分高血压、高血糖、血脂异常、超重进行调整后尿液p H偏低组的HR值为1.20(95%CI:1.07~1.35,P<0.05),进一步对饮食、吸烟和饮酒因素调整后的HR值为1.17(95%CI:1.05~1.32,P<0.05)。结论尿液p H偏低是Met S的独立危险因素。
Objective To investigate the relationship between urinary p H and metabolic syndrome (Met S). Methods Longitudinal cohort was established in 8 720 healthy subjects at the Health Examination Center of Shandong Provincial Hospital Affiliated to Shandong University. The relationship between urinary p H and Met S was explored by Cox proportional hazards model. Results After an average of 2003 years of follow-up, a total of 1 657 Met S were present with an incidence density of 62.79 / 1 000 (1 657/26 389) person-years. The adjusted risk ratio (HR) was 1.36 (95% CI: 1.21-1.53, P <0.05) when only age-adjusted urinary p H level was low. On the basis of this, the risk factors of hypertension, hyperglycemia, The HR of 1.12 (95% CI: 1.07-1.35, P <0.05) was further adjusted to be 1.17 (95% CI: 1.07-1.35, P <0.05) after adjusted for dyslipidemia and overweight. % CI: 1.05 ~ 1.32, P <0.05). Conclusion The low urinary p H is an independent risk factor of Met S.