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目的探讨健康男性青年服用β受体阻滞剂卡维地洛后不同血药浓度下静息心电图QT间期离散度(QTd)与用药前比较有无显著性变化,以对卡维地洛的抗心律失常作用机制提供依据。方法对20名健康男青年在服用卡维地洛20 mg前及服药后0.5、1、2、3、4、6、8、10、24 h分别测血药浓度,并做静息心电图,于十二导联心电图测量Q-T间期离散度。并将数据进行统计分析。结果随着血药浓度的升高,QTd有缩小趋势,但与用药前比较各P值无显著性差异。结论卡维地洛对正常健康男性的QTd可能无影响,从反面证实,它主要对有病理情况下的心脏病患者有抗心律失常作用。
Objective To investigate the QTd of resting electrocardiogram (QTd) in healthy male youth after taking carvedilol, which has different concentrations of beta-blocker, compared with before treatment, Antiarrhythmic mechanism of action to provide the basis. Methods 20 healthy young men before taking carvedilol 20 mg and 0.5,1,2,3,4,6,8,10,24 h after taking drug concentration were measured, and resting ECG, at Twelve - lead ECG measurement QT interval dispersion. And the data for statistical analysis. Results With the increase of plasma concentration, QTd showed a trend of decrease, but there was no significant difference between each P value and before treatment. Conclusion Carvedilol may not affect the QTd of normal healthy men. On the contrary, it has been proved that it is mainly antiarrhythmic for heart disease patients with pathological conditions.