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目的评价贝那普利联合左旋氨氯地平治疗2级和3级原发性高血压的降压稳定性。方法选取40例2级和3级原发性高血压患者,口服贝那普利10mg/d和左旋氨氯地平2.5mg/d,疗程8周。治疗前及治疗后分别进行24h动态血压监测,计算治疗后的谷峰比值与平滑指数。结果治疗8周后:日间、夜间及24h平均血压较治疗前均有下降,且差异具有统计学意义(P<0.01);收缩压和舒张压的谷峰比值各自达到76%与71%,而二者的平滑指数分别高至1.13及1.09。结论贝那普利联合左旋氨氯地平治疗2级和3级原发性高血压具有明显的平稳降压效果。
Objective To evaluate the antihypertensive stability of benazepril combined with levamlodipine in the treatment of patients with grade 2 and 3 essential hypertension. Methods Forty patients with grade 2 and 3 essential hypertension were enrolled in this study. The patients were treated with benazepril 10 mg / d and levamlodipine 2.5 mg / d orally for 8 weeks. 24h before and after treatment, ambulatory blood pressure monitoring were calculated after treatment, the ratio of peak to valley and smoothing index. Results After 8 weeks of treatment, mean blood pressure decreased day by day, night and 24h before treatment, and the difference was statistically significant (P <0.01). The peak-to-peak systolic and diastolic blood pressures reached 76% and 71% The smoothness index of both is as high as 1.13 and 1.09 respectively. Conclusion The combination of benazepril and levamlodipine in the treatment of grade 2 and 3 essential hypertension has obvious antihypertensive effect.