论文部分内容阅读
目的评价 1 5 3Sm-乙二胺四甲基膦酸 (1 5 3Sm-EDTMP)治疗恶性肿瘤多发性骨转移疼痛的疗效。方法按照治疗适应症 ,对 2 16例经临床或病理证实为恶性肿瘤多发性骨转移患者进行单次或多次 1 5 3Sm-EDTMP治疗 ,随访观察疗效及不良反应 ,治疗后每 1～ 2周测定血白细胞、血小板、血红蛋白 ,每月测定肝、肾功能生化指标。结果全组总有效率为 84.3% ,其中完全缓解 2 7.8% ,部分缓解 5 6 .5 % ,无效 15 .7%。患者临床情况、治疗方法、既往治疗与治疗效果无明确关系 ,恶性肿瘤类型与治疗效果有一定相关性。副作用主要为骨髓抑制 ,经治疗后 1～ 2个月内皆能恢复 ,肝、肾功能未见明显变化。结论 1 5 3 Sm-EDTMP治疗多发性骨转移癌 (骨痛 )疗效好 ,副作用少 ,使用安全 ,能有效改善患者的生活质量
Objective To evaluate the efficacy of 1 5 3Sm-ethylenediamine tetramethylphosphonic acid (1 5 3Sm-EDTMP) in the treatment of multiple bone metastasis pain in malignant tumors. Methods According to treatment indications, single or multiple 153Sm-EDTMP treatment was performed in 216 patients with clinically or pathologically confirmed multiple bone metastases of malignant tumors. The efficacy and adverse reactions were followed up for 1 to 2 weeks after treatment. Blood white blood cells, platelets, and hemoglobin were measured, and liver and kidney function biochemical parameters were measured monthly. Results The total effective rate of the whole group was 84.3%, of which complete relief was 27.8%, partial relief was 56.5%, and invalid was 15.7%. There is no clear relationship between clinical conditions, treatment methods, previous treatments, and treatment effects. There is a certain correlation between the type of malignant tumor and the treatment effect. The main side effects were myelosuppression, which could be restored within 1 to 2 months after treatment. There was no significant change in liver and kidney function. Conclusions 1 5 3 Sm-EDTMP is effective in the treatment of multiple bone metastases (bone pain), with fewer side effects and safe use, and can effectively improve the quality of life of patients.