目的观察更昔洛韦联合丙种球蛋白治疗巨细胞病毒(CMV)性肝炎的疗效。方法将52例CMV肝炎患儿随机分成对照组与治疗组,对照组给一般保肝退黄治疗,治疗组加用更昔洛韦和丙种球蛋白。结果治疗组有效率明显高于对照组(P<0.05)。治疗1月后,治疗组的胆红素、转氨酶均较对照组明显降低,治疗3月与1月比较,胆红素、转氨酶又有明显降低(P<0.01);定期进行血常规、肝肾功能检查,未见明显不良反应。结论更昔洛韦联合丙种球蛋白治疗婴儿CMV肝炎的疗效显著、安全,值得临床推广。 Objective To observe the curative effect of ganciclovir combined with gamma globulin in the treatment of cytomegalovirus (CMV) hepatitis. Methods Fifty-two children with CMV hepatitis were randomly divided into control group and treatment group. The control group was given general liver protection and yellowing treatment. The treatment group was given ganciclovir and gamma globulin. Results The effective rate of the treatment group was significantly higher than that of the control group (P <0.05). The levels of bilirubin and aminotransferase in the treatment group were significantly lower than those in the control group after 1 month of treatment. The levels of bilirubin and aminotransferase were significantly decreased in March and January (P <0.01) Functional tests, no obvious adverse reactions. Conclusion Ganciclovir combined with gamma globulin in the treatment of infantile CMV hepatitis is significant and safe and worthy of clinical promotion.