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目的:探讨感染对儿童初发系统性红斑狼疮病情活动度的影响。方法:通过回顾性研究收集儿童系统性红斑狼疮病例86例,通过整理病史、体格检查及统计实验室检查结果等方法统计相关临床及实验室资料。根据以上资料分为感染组和对照组,通过比较分析两组资料探讨感染对初发儿童SLE病情活动度的影响情况。结果:1)SLE患儿感染发生率为52.3%,感染部位以呼吸道多见,占40%,其次为消化道和泌尿道,病原体以细菌多见,占62.2%,其次为支原体、病毒;2)感染组的ds-DNA、CD3~+CD8~+(Ts)细胞、CD3~-CD19~+(B)细胞、SLEDAI评分均明显高于对照组(P<0.05);感染组补体数量明显低于对照组(P<0.05),感染组抗感染治疗后,ds-DNA、CD3~+CD8~+(Ts)细胞、SLEDAI评分较治疗前明显下降(P<0.05),而补体数量及CD3~-CD16~+CD56~+(%)细胞较治疗前明显上升(P<0.05)。结论:儿童SLE患者较易合并感染,发病初期及合并感染会加重儿童系统性红斑狼疮的病情,及时有效控制感染有助于改善儿童SLE患者的病情。
Objective: To investigate the impact of infection on the incidence of systemic lupus erythematosus in children. Methods: A retrospective study was conducted to collect 86 cases of systemic lupus erythematosus (SLE) in children. The clinical and laboratory data were collected by sorting out medical history, physical examination and statistical laboratory test results. According to the above information is divided into infection group and control group, by comparing the two groups of data to explore the impact of infection on the incidence of SLE activity in children with primary. Results: 1) The incidence of SLE infection in children was 52.3%. Most of the infections were respiratory tract, accounting for 40%, followed by digestive tract and urinary tract. The most common pathogens were bacteria (62.2%), followed by mycoplasma and virus ) Infection group was significantly higher than that of the control group (P <0.05). The number of CD3 ~ + CD8 ~ + (Ts) cells, CD3 ~ -CD19 ~ The levels of ds-DNA, CD3 + CD8 + T cells and SLEDAI in the infected group were significantly lower than those before treatment (P <0.05), while the number of complement and CD3 ~ -CD16 ~ + CD56 ~ + (%) cells were significantly increased compared with those before treatment (P <0.05). Conclusion: Children with SLE are more susceptible to co-infection. Early onset and co-infection may aggravate the disease in children with systemic lupus erythematosus (SLE). Controlling infection timely and effectively can improve the condition of children with SLE.