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目的:一些文章论述了关于吸烟和被动吸烟与结核病(TB)表现和结局之间的关系,我们对这些文章中的证据进行评估。由于吸烟和TB之间的关联一直没有得到普遍认可,防治TB的临床医生和公共卫生人员可能没有意识到他们在烟草控制方面应起的作用。因此,我们进行了定性系统综述和Meta分析。方法:搜索参考文献清单、PubMed、国际防痨和肺部疾病联合会数据库及Google学术搜索,最终纳入包含53个结果的英文文章42篇,作为提取的数据。对每一研究进行质量评分,以便按各TB治疗转归情况进行分类。然后将纳入研究的结果进行Meta分析。结果:尽管可用资料有限,但显示出吸烟与TB具有较强的关联,被动吸烟与TB之间、吸烟与复治TB之间有中度关联;吸烟与结核分枝杆菌感染之间、吸烟与TB死亡率之间的关联证据有限。支持吸烟与延误、丢失、痰菌阴转缓慢、病情加重或耐药TB之间相关性的证据不足,也没有证据表明被动吸烟与感染有关。结论:吸烟与TB之间存在因果关系,吸烟对TB产生多方面重要影响,临床医生劝说病人戒烟和避免被动吸烟是控制TB重要措施之一。
Aims: Some articles discuss the relationship between smoking and passive smoking and tuberculosis (TB) performance and outcomes, and we evaluate the evidence in these articles. As the association between smoking and TB has not been universally recognized, clinicians and public health workers fighting TB may not be aware of their role in tobacco control. Therefore, we conducted a qualitative systematic review and meta-analysis. METHODS: A searchable list of references, PubMed, the International Society for Tuberculosis and Lung Diseases database and Google Scholar, was finally included in the 42 articles containing 53 articles as extracted data. Quality scores were scored for each study to classify the outcomes of each TB treatment. The results of the included studies were then analyzed by meta-analysis. RESULTS: Despite the limited data available, smoking was shown to be strongly associated with TB, with a moderate association between passive smoking and TB and between smoking and retreatment TB; between smoking and M. tuberculosis, between smoking and There is limited evidence of association between TB mortality. There is not enough evidence to support the association between smoking and delays, loss, slow sputum phlegm overcast, exacerbations or resistance to TB, and there is no evidence that passive smoking is associated with infection. Conclusion: There is a causal relationship between smoking and TB. Smoking has many important effects on TB. It is one of the important measures to control TB that clinicians should persuade patients to quit smoking and avoid passive smoking.