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目的探讨1,6-二磷酸果糖联合复方丹参注射液治疗新生儿窒息并发心肌损伤的临床疗效。方法选取怀化巿第二人民医院靖州医院2013年1月—2016年1月收治的新生儿窒息患儿100例,随机分为B组和A组,各50例。B组患儿采用常规综合治疗,A组患儿在B组基础上给予1,6-二磷酸果糖联合复方丹参注射液治疗,两组患者均持续治疗2周。比较两组患儿的临床疗效及治疗前后心肌酶指标[磷酸肌酸激酶、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)]。结果 A组患儿治疗总有效率高于对照组(P<0.05)。治疗前,两组患儿磷酸肌酸激酶、CK-MB、cTnT水平比较,差异无统计学意义(P>0.05);治疗后,A组患儿磷酸肌酸激酶、CK-MB、cTnT水平低于对照组(P<0.05)。结论采用1,6-二磷酸果糖联合复方丹参注射液治疗新生儿窒息并发心肌损伤的临床疗效确切,可有效改善患儿心肌酶。
Objective To investigate the clinical efficacy of fructose-1,6-diphosphate combined with salvia miltiorrhiza in the treatment of neonatal asphyxia complicated with myocardial injury. Methods 100 cases of neonatal asphyxia in Jingzhou Hospital of Huaihua Second People’s Hospital from January 2013 to January 2016 were randomly divided into group B and group A, 50 cases in each group. The patients in group B were treated by conventional comprehensive therapy. The children in group A were given fructose-1,6-diphosphate combined with salvia miltiorrhiza injection on the basis of group B. The patients in both groups were treated for 2 weeks. The clinical efficacy of the two groups of children were compared before and after treatment of myocardial enzymes [creatine phosphokinase, creatine kinase (CK-MB), troponin T (cTnT)]. Results The total effective rate of treatment in children in group A was higher than that in control group (P <0.05). Before treatment, the levels of creatine phosphokinase, CK-MB and cTnT in two groups had no significant difference (P> 0.05). After treatment, the levels of creatine phosphokinase, CK-MB and cTnT in group A were lower In the control group (P <0.05). Conclusion Fructose-1,6-diphosphate combined with Salvia miltiorrhiza injection is effective in treating neonatal asphyxia complicated with myocardial injury and can effectively improve myocardial enzymes in children.