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目的探讨精浆中性α糖苷酶(NAG)和血清促卵泡生成素(FSH)联合检测在梗阻性无精子症诊断中的意义。方法分析24例男性无精子症患者(14例为梗阻性无精子症,10例为非梗阻性无精子症)精浆NAG和FSH水平,与16例健康已生育男性(正常对照组)的检测结果进行相关性分析,同时结合睾丸体积和详细的病史资料判断无精子症病因及分型。结果无精子症患者(包括梗阻性和非梗阻性无精子症组)与正常对照组年龄差异无统计学意义(P>0.05),非梗阻性无精子症组睾丸体积明显比梗阻性无精子症组和正常对照组小(P<0.01)。无精子症患者NAG含量均明显低于正常对照组(P<0.01),FSH水平均明显高于正常对照组(P<0.01);梗阻性无精子症组NAG和血清FSH水平明显低于非梗阻性无精子症组(P<0.01)。结论精浆NAG和血清FSH联合检测具有经济、快速、安全、无创等优点,对无精子症的诊断和临床指导治疗具有重要意义。
Objective To explore the significance of combined detection of seminal plasma alpha-glucosidase (NAG) and serum follicle-stimulating hormone (FSH) in the diagnosis of obstructive azoospermia. Methods Serum levels of NAG and FSH in seminal plasma of 24 male patients with azoospermia (14 with obstructive azoospermia and 10 with non-obstructive azoospermia) were analyzed and compared with 16 healthy male fertile men (normal controls) Results Correlation analysis, combined with testicular volume and detailed medical history to determine the cause and type of azoospermia. Results There was no significant difference in the age of patients with azoospermia (including obstructive and non-obstructive azoospermia) and normal controls (P> 0.05). The testicular volume in non-obstructive azoospermia group was significantly higher than that in obstructive azoospermia Group and normal control group was small (P <0.01). The levels of NAG in patients with azoospermia were significantly lower than those in normal control group (P <0.01), FSH levels were significantly higher than those in normal control group (P <0.01); NAG and serum FSH levels in obstructive azoospermia group were significantly lower than those in non-obstructive Azoospermia group (P <0.01). Conclusion The combination of seminal plasma NAG and serum FSH has the advantages of economy, rapidness, safety and noninvasiveness. It is of great significance for the diagnosis and clinical treatment of azoospermia.