Background: Plateau zokor inhabits in sealed burrows from 2,000 to 4,200 meters at Qinghai-Tibet Plateau.This extreme living environment makes it a great model to study animal adaptation to hypoxia,low temperature,and high carbon dioxide concentration.Methods: We provide an integrated resource,ZokorDB,for tissue specific regulatory network annotation for zokor.ZokorDB is based on a high-quality draft genome of a plateau zokor at 3,300 m and its transcriptional profiles in brain,heart,liver,kidney,and lung.The conserved non-coding elements ofzokor are annotated by their nearest genes and upstream transcriptional factor motif binding sites.Results: ZokorDB provides a general draft gene regulatory network (GRN),i.e.,potential transcription factor (TF) binds to non-coding regulatory elements and regulates the expression of target genes (TG).Furthermore,we refined the GRN by incorporating matched RNA-seq and DNase-seq data from mouse ENCODE project and reconstructed five tissue-specilic regulatory networks.Conclusions: A web-based,open-access database is developed for easily searching,visualizing,and downloading the annotation and data.The pipeline of non-coding region annotation for zokor will be useful for other non-model species.ZokorDB is free available at the website (bigd.big.ac.cn/zokordb/).