目的探讨干扰素α治疗严重急性呼吸综合征的效果。方法严重急性呼吸综合征患者87例,其中41例给予糖皮质激素联合干扰素α治疗作为干扰素组,余46例给予糖皮质激素治疗作为对照组。比较两组患者在发热持续时间、住院天数、X线胸片显示病灶吸收时间和对激素需求量的差异。结果两组患者的发热持续时间无显著性差异,干扰素组患者的住院时间、X线胸片好转时间和对激素的需求量明显少于对照组。结论严重急性呼吸综合征急性期患者联合使用干扰素α治疗,可缩短患者的住院时间,促进肺部病变的吸收,减少对激素的需求量,但不会缩短发热持续时间。 Objective To investigate the effect of interferon α in the treatment of severe acute respiratory syndrome. Methods 87 patients with severe acute respiratory syndrome, of which 41 patients given glucocorticoid combined with interferon α as an interferon group, and 46 patients given glucocorticoid treatment as a control group. The duration of fever, days of hospitalization, radiographs of lesions, and the differences in hormone requirements were compared between the two groups. Results There was no significant difference in the duration of fever between the two groups. The duration of hospitalization, the improvement time of X-ray and the demand for hormone in the interferon group were significantly less than those in the control group. Conclusion The combination of interferon α therapy in patients with acute severe acute respiratory syndrome can shorten the hospital stay, promote the absorption of lung lesions and reduce the demand for hormones, but will not shorten the duration of fever.