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目的探讨绝经后2型糖尿病(T2DM)患者与骨质疏松相关性。方法选取86例在本科住院的绝经后T2DM患者为研究组,均符合1999年WHO T2DM诊断标准。另选78例非T2DM绝经女性为对照组,采用双光能X线骨密度检测仪对患者进行腰椎L2~4和左侧股骨近端(包括Neck、Troch、Ward三角区)骨密度测量,并测定空腹血糖(FBG)、糖化血红蛋白(HbA1c)、甘油三脂(TG)、胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C),结合年龄、病程、绝经年限等因素进行研究。结果两组FBG、HbA1c、TG、LDL-C差异有统计学意义(P<0.05),绝经后T2DM组Neck、Ward三角区、Troch骨密度均低于正常对照组,差异有统计学意义(P<0.05),两组年龄、绝经年限的比较差异无统计学意义(P>0.05)。结论绝经后T2DM患者更易发生骨质疏松,骨折的危险性也高于非T2DM绝经女性,早期筛查血糖及骨密度具有重要意义。
Objective To investigate the association between osteoporosis and postmenopausal type 2 diabetes mellitus (T2DM). Methods Totally 86 postmenopausal T2DM patients were enrolled in this study. All of them were in line with the diagnostic criteria of WHO T2DM in 1999. Another 78 non-T2DM women were selected as the control group. Bone mineral density measurements of lumbar L2 ~ 4 and proximal femur (including Neck, Troch, Ward triangle) were performed by dual-beam X-ray absorptiometry The levels of fasting blood glucose (FBG), HbA1c, TG, TC, HDL-C and LDL-C were measured and their age, course of disease, Menopause and other factors to study. Results The FBG, HbA1c, TG and LDL-C in the two groups were significantly different (P <0.05). The bone mineral density of Neck, Ward triangle and Troch in postmenopausal T2DM group were lower than that in the normal control group <0.05). There was no significant difference between the two groups in age and menopause (P> 0.05). Conclusion Postmenopausal T2DM patients are more prone to osteoporosis, the risk of fracture is also higher than non-T2DM menopausal women, early screening of blood glucose and bone mineral density is of great significance.