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目的探讨下颌下腺上皮性肿瘤的临床特征及诊疗要点。方法对25例经病理证实为下颌下腺上皮性肿瘤患者的临床资料进行回顾性分析。结果25例患者中,良性肿瘤13例,恶性肿瘤12例;发病平均年龄为61岁;男女为1.15:1。良性肿瘤主要为多形性腺瘤,而恶性肿瘤以腺样囊性癌最常见,其次是黏液表皮样癌。手术是良性肿瘤的惟一治疗方法,术后均没出现复发。大部分恶性肿瘤患者行手术和放疗相结合,术后3年生存率为75.0%;5年生存率为66.7%。结论良性肿瘤表现为缓慢生长的肿块,摘除肿瘤及下颌下腺是其安全有效的治疗方法。恶性肿瘤治疗应行根治术和术后放疗,预后主要取决于肿瘤的组织学类型和生物学特性。
Objective To investigate the clinical features and diagnosis and treatment of submandibular gland epithelial tumor. Methods The clinical data of 25 patients with pathologically confirmed submandibular glandular epithelial tumor were analyzed retrospectively. Results Of the 25 patients, 13 were benign tumors and 12 were malignant tumors. The mean age of onset was 61 years and that of men and women was 1.15: 1. Benign tumors are mainly pleomorphic adenomas, while adenocarcinoma is the most common malignant tumor, followed by mucoepidermoid carcinoma. Surgery is the only treatment of benign tumors, no recurrence after surgery. The majority of patients with malignant tumors underwent surgery combined with radiotherapy. The 3-year survival rate was 75.0% and the 5-year survival rate was 66.7%. Conclusions Benign tumors show slowly growing lumps. Removal of tumors and submandibular glands is a safe and effective treatment. Malignant tumors should be treated by radical mastectomy and postoperative radiotherapy. The prognosis depends mainly on the histological type and biological characteristics of the tumor.