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目的 :探讨 型糖尿病 (T2 DM)患者血清尿酸水平变化与颈动脉粥样硬化的关系。方法 :检测 10 2例 型糖尿病患者病程、空腹血糖、餐后血糖、体质量指数 (BMI)、血压、血清胆固醇、甘油三脂、尿酸、肾功 5项、心脏收缩和舒张功能。按是否有动脉粥样硬化分为 2组。结果 :在 T2 DM并发动脉粥样硬化组血清尿酸水平显著升高 (P<0 .0 1) ,心脏舒张功能显著降低 (P<0 .0 1) ,尿 β2 、α2 微球蛋白 ,AL b排泄增加 (均 P<0 .0 1)。结论 :T2 DM患者颈动脉粥样硬化时血清尿酸水平升高 ,同时伴心脏舒张功能损伤 ,这种尿酸变化可能与肾小管的损伤有关。
Objective: To investigate the relationship between serum uric acid level and carotid atherosclerosis in type 2 diabetes mellitus (T2DM). Methods: The duration of diabetes, fasting blood glucose, postprandial blood glucose, body mass index (BMI), blood pressure, serum cholesterol, triglyceride, uric acid and renal function, cardiac systolic and diastolic function were detected in 102 patients with type 2 diabetes mellitus. According to whether there is atherosclerosis divided into two groups. Results: Serum uric acid levels were significantly increased in T2DM complicated with atherosclerosis (P <0.01), diastolic function was significantly decreased (P <0.01), urinary β2, α2 microglobulin, ALb Excretion increased (P <0. 01). CONCLUSION: Serum uric acid levels in T2DM patients with carotid atherosclerosis are elevated, accompanied by impairment of cardiac diastolic function. This change in uric acid may be related to renal tubular injury.