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建立豚鼠哮喘模型，检测肺活组织、支气管肺泡灌洗液（ＳＡＬＦ）、血浆内皮素－１（ＥＴ－１）水平及地塞米松干预后的变化以探讨ＥＴ－１在支气皆哮喘发病中的作用。结果显示哮喘组肺活组织、ＢＡＬＦ、血浆ＥＴ－１显著升高；吸入地塞米松后ＥＴ－１均显著下降。提示：ＥＴ－１可能参与支气管哮喘的发生和发展，吸入糖皮质激素可以抑制体内ＥＴ－１的生成和释放，这可能是糖皮质激素治疗支气管哮喘的重要机制之一。
To establish a guinea pig asthma model to detect the changes of lung tissue, bronchoalveolar lavage fluid (SALF), plasma endothelin-1 (ET-1) and dexamethasone after intervention to explore the pathogenesis of bronchial asthma Role. The results showed that lung tissue, BALF, plasma ET-1 in asthma group were significantly increased; ET-1 decreased significantly after dexamethasone inhalation. It is suggested that ET-1 may be involved in the development and progression of bronchial asthma. Inhaled glucocorticoid can inhibit ET-1 production and release in vivo, which may be one of the important mechanisms of glucocorticoid treatment of bronchial asthma.