前列腺增生症(benign prostatic hyperplasia, BPH)是老年男性常见泌尿外科疾病。流行病学资料显示:BPH随着年龄增加发病率逐渐上升,其中半数左右患者因膀胱出口梗阻而导致下尿路症状、急性尿潴留、反复泌尿系感染、肾功能损害等,需要临床干预治疗。近年研究发现局部缺血缺氧在BPH发病机制中起着重要作用,本文就相关研究作一综述。 Benign prostatic hyperplasia (BPH) is a common urological disease in elderly men. Epidemiological data show that the incidence of BPH increases with age, of which about half of patients due to bladder outlet obstruction caused by lower urinary tract symptoms, acute urinary retention, recurrent urinary tract infections, renal dysfunction, the need for clinical intervention. In recent years, studies have found that ischemia and hypoxia play an important role in the pathogenesis of BPH. This article reviews the related research.