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SP广泛地分布于中枢和外周组织 ,呈现出复杂的生理效应。它与临床的多种疾病有关 ,如帕金森氏病、亨廷顿氏病、胃肠道炎症、膀胱炎、风湿病、头痛、变异性心绞痛、脊髓空洞症等。SP的拮抗剂如sendide,spantide ,CP 963 4 5,RP67580 ,SP4 8968,CP 1 2 2 72 1等通过阻断SP的作用可产生镇痛、止泻、解痉、止喘、抗炎和抗伤害等效应 ,在临床有一定的应用前景。
SP is widely distributed in the central and peripheral tissues, showing a complex physiological effects. It is associated with a variety of clinical diseases such as Parkinson’s disease, Huntington’s disease, gastrointestinal inflammation, cystitis, rheumatism, headache, variant angina, syringomyelia and so on. Antagonists of SP such as sendide, spantide, CP 963 4 5, RP67580, SP4 8968, CP 1 2 2 72 1 and the like can produce analgesic, antidiarrheal, antispasmodic, antiasthmatic, anti-inflammatory and anti- Injury and other effects, in the clinical application of certain prospects.