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原发性系膜增生性肾炎(mesangial proliferative glomerulonephritis,简称MsPGN)依其免疫病理特点可分为IgA肾病、IgM肾病、Ig和/或C_3其它模式沉积的MsPGN、无Ig、无C_3沉积的MsPGN等4型。有人将Ⅲ型新月体肾炎(即肾组织内无Ig、无C_3沉积者)称为寡免疫复合物型新月体肾炎。参照此观点,我们将无Ig、无C_3沉积的MsPGN称之为寡免疫复合物性MsPGN(pauci-immune MsPGN,PI-MsPGN),临床上较为少见,其发病机理亦不明了。现对18例PI-MsPGN的临床病理资料分析报告如下:
According to its immunopathological features, mesangial proliferative glomerulonephritis (MsPGN) can be divided into IgA nephropathy, IgM nephropathy, MsPGN deposited in other modes of Ig and / or C_3, MsPGN without Ig, C_3 -positive 4 type. Some people will type Ⅲ crescentic nephritis (ie, no Ig in renal tissue, no C_3 sedimentation) as oligoimmunoconjugate crescentic nephritis. With reference to this view, we call MsPGN without Ig, without C_3 deposition as a pauc-immune MsPGN (pauci-immune MsPGN, PI-MsPGN), which is rare in clinic and its pathogenesis is unknown. Now 18 cases of PI-MsPGN clinical and pathological data analysis report as follows: