论文部分内容阅读
目的 进一步研究病毒性乙型肝炎的发病机制 .方法 采用 APAAP技术和 EL1SA法检测 92例慢性乙型肝炎患者 T细胞亚群和血清 s IL - 2 R,TNF-α和 IL - 6水平 .结果 发现慢性乙型肝炎患者 CD4+细胞数较正常低 ,CD8+细胞和血清中 s IL- 2 R,TNF- α和 IL- 6水平明显增高 .在慢性肝炎、肝硬化患者活动期与稳定期之间 ,重型肝炎患者的肝坏死期与恢复期之间 ,血清 TNF- α和 IL- 6二项指标的差异有显著性 ,均 P<0 .0 1.结论 表明乙肝患者存着免疫调节紊乱 ,而免疫异常至少有部分原因是细胞因子的作用
Objective To further study the pathogenesis of viral hepatitis B. Methods The levels of T lymphocyte subsets and serum levels of IL - 2 R, TNF - α and IL - 6 in 92 patients with chronic hepatitis B were detected by APAAP and EL1SA. The number of CD4 + cells in patients with chronic hepatitis B was lower than normal, and the levels of s IL-2R, TNF-α and IL-6 in CD8 + cells and serum were significantly increased.In patients with chronic hepatitis and cirrhosis, There was a significant difference between the two indexes of serum TNF-α and IL-6 in patients with hepatic necrosis and convalescence, all P <0. 1. The conclusion shows that immunological disorders are present in patients with hepatitis B, At least in part because of the role of cytokines