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目的 观察中药成方四君子汤对大鼠去卵巢 90天血清骨钙素水平的变化。方法 2 8只 3月龄 SD雌性大鼠随机分组 :假手术组、去卵巢组和四君子汤药物组。实验 90天 ,处死大鼠心室取血 ,离心血清检测骨钙素。结果 去卵巢组与假手术组比 ,BGP显著升高 ( P<0 .0 1) ,四君子汤组与假手术组基本在同一水平 ,较去卵巢组低 30 % ( P<0 .0 1)。结论 本文结果显示四君子汤能抑制大鼠去卵巢 90天血清骨钙素升高的变化
Objective To observe the changes of serum osteocalcin levels in 90 days of ovariectomized rats by the traditional Chinese medicine Cheng-Fang Sijunzi decoction. Methods Twenty-eight SD female rats aged 3 months were randomly divided into two groups: sham operation group, ovariectomized group and Sijunzi decoction group. In the experiment for 90 days, the rats were sacrificed and blood samples were taken from the heart to measure osteocalcin by centrifugation. Results Compared with the sham-operated group, BGP significantly increased (P<0.01), Sijunzi Decoction group and sham-operated group were basically at the same level, which was 30% lower than that in the ovariectomized group (P<0.01). . Conclusion The results of this study show that Sijunzi decoction can inhibit the changes of serum osteocalcin levels in ovariectomized rats for 90 days.