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目的探讨丹参联合异甘草酸镁治疗药物性肝损害的有效性和安全性。方法将我院48例药物性肝损害患者随机分为两组,对照组给予还原型谷胱甘肽治疗,试验组给予丹参联合异甘草酸镁注射液治疗。比较两组患者治疗前后肝功能指标、治疗总有效率和不良反应发生率。结果治疗后,试验组肝功能较对照组明显改善(P<0.05),总有效率显著高于对照组(P<0.05);两组患者均无严重不良反应发生。结论采用丹参联合异甘草酸镁治疗药物性肝损害疗效确切,能显著改善患者临床症状和肝功能,不良反应少。
Objective To explore the efficacy and safety of Danshen combined with magnesium isrimazole in the treatment of drug-induced liver damage. Methods 48 cases of drug-induced liver damage in our hospital were randomly divided into two groups, the control group was treated with reduced glutathione, the experimental group was given Danshen combined with magnesium isoglycyrrhizinate injection. The liver function indexes, the total effective rate of treatment and the incidence of adverse reactions were compared between the two groups before and after treatment. Results After treatment, the liver function of the experimental group was significantly improved (P <0.05), and the total effective rate was significantly higher than that of the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Danshen combined with magnesium isoglycyrrhizinate for the treatment of drug-induced liver damage is effective, can significantly improve the clinical symptoms and liver function in patients with less adverse reactions.