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通过2-甲基-4-三氟甲基-5-噻唑甲酰氯与苯胺或氨基吡啶类化合物反应,合成了7个未见文献报道的N-取代2-甲基-4-三氟甲基-5-噻唑甲酰胺类化合物,其结构均经核磁共振氢谱、红外光谱、高分辨质谱和元素分析的表征和确认。对8种病原菌进行的初步杀菌活性测试结果表明:目标化合物在50μg/mL下对水稻纹枯病菌Pellicularia sasakii的活性最好(抑制率在72.60%～91.78%之间),其中6a的抑制率最高。
Seven novel N-substituted 2-methyl-4-trifluoromethyl (N-substituted 2-methyl-4-trifluoromethyl) compounds were synthesized by the reaction of 2-methyl-4-trifluoromethyl-5-thiazolecarboxylic acid chloride with aniline or aminopyridine compounds -5-thiazolecarboxamides. Their structures were characterized and confirmed by 1H NMR, IR, HRMS and elemental analysis. The preliminary bactericidal activity tests on eight kinds of pathogenic bacteria showed that the target compound had the best activity against Pellicularia sasakii at the concentration of 50μg / mL (the inhibition rate was between 72.60% and 91.78%), and the inhibitory rate of 6a highest.