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目的:分析腹泻型肠易激综合征(IBS)患者外周血Th1/Th2细胞因子失衡表达。方法:连续选择近期就诊的腹泻型IBS患者27例,对照组为31例同龄、同性别的同期健康体检者。两组对象接受了外周血Th相关细胞因子γ-干扰素(IFN-γ)、白细胞介素-4(IL-4)检测,并计算IFN-γ/IL-4比值。结果:腹泻型IBS组外周血IFN-γ浓度及IFN-γ/IL-4比值均明显高于对照组,而血清IL-4浓度则显著低于后者(P均<0.05～0.01)。结论:腹泻型IBS患者存在明确Th1优势失衡表达。
Objective: To analyze the unbalanced expression of Th1 / Th2 cytokines in peripheral blood of patients with diarrhea-predominant irritable bowel syndrome (IBS). Methods: A total of 27 consecutive IBS patients with diarrhea were selected. The control group consisted of 31 healthy controls of the same age and same sex. The two groups received Th-related cytokines IFN-γ and IL-4, and calculated IFN-γ / IL-4 ratio. Results: The concentration of IFN-γ and the ratio of IFN-γ / IL-4 in peripheral blood were significantly higher in diarrhea-predominant IBS patients than those in control group, while the serum IL-4 levels were significantly lower than those in control group (all P <0.05-0.01). Conclusion: There is a clear imbalance of Th1 expression in patients with diarrhea-type IBS.