创伤愈合有两种形式,完全性修复(即再生)和瘢痕性愈合。转化生长因子-β(transforming growth factorβ,TGF-β)是迄今为止与创伤愈合关系最为密切的生长因子,TGF-β至少有6个亚型,各亚型之间有64%~82%的同源性[1],在成人皮肤组织中,TGF-β1、β2、β3三种异构体均有阳性表达。TGF-β1、β2、β3参与创伤愈合的诸多步骤:炎症反应、促血管新生、成纤维细胞增殖、胶原合成与分解以及新的ECM重建。以往研究大都聚焦于TGF-β亚型对创伤愈合的促进作用,但TGF-β亚 There are two forms of wound healing, complete repair (ie regeneration) and cicatricial healing. Transforming growth factor-β (TGF-β) is by far the most closely related to wound healing. TGF-β has at least 6 subtypes with 64% -82% Source [1], in adult skin tissue, TGF-β1, β2, β3 three isoforms were positive expression. TGF-β1, β2, β3 are involved in many steps of wound healing: inflammation, pro-angiogenesis, fibroblast proliferation, collagen synthesis and degradation, and new ECM remodeling. Most previous studies focused on the promotion of TGF-β subtype on wound healing, but TGF-β subunit