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目的 :研究 p5 3、nm2 3和c -erbB - 2蛋白在子宫内膜癌中的表达及其临床意义。方法 :用LSAB免疫组化法检测 42例子宫内膜癌中p5 3、nm2 3和c-erbB - 2蛋白的表达。结果 :p5 3 ,nm2 3,c -erbB - 2在子宫内膜癌中的阳性率分别为 31.0 %、6 0 .0 %、47.6 % ,其阳性表达与年龄、不同组织学类型差异无显著性 (P >0 .0 5 ) ;p5 3与病理分级有关 ,随着细胞分级的增高 ,其阳性率逐步升高 ,差异有极显著性 ( χ2 =16 .3,P <0 .0 0 5 ) ;nm2 3与病理分级呈负相关 (P <0 .0 1) ,无淋巴结转移者阳性表达率明显高于有淋巴结转移者 ( 71.9%和 2 0 .0 % ,P <0 .0 5 ) ;c -erbB - 2的表达与癌细胞的分化程度、临床分期有关 ,分化程度高及早期癌中c -erbB - 2表达强。结论 :对子宫内膜癌进行p5 3、nm2 3和c -erbB - 2蛋白的检测 ,有助于预测子宫内膜癌的发生、演进、转移和预后。
Objective: To study the expression of p5 3, nm23 and c-erbB-2 in endometrial carcinoma and its clinical significance. Methods: The expressions of p5 3, nm23 and c - erbB - 2 in 42 cases of endometrial carcinoma were detected by LSAB immunohistochemistry. Results: The positive rates of p5 3, nm23 and c-erbB-2 in endometrial carcinoma were 31.0%, 60.0% and 47.6%, respectively. There was no significant difference in the expression of p53, nm23, c-erbB- (P> 0.05); p5 3 and pathological grade, with the increase of cell grade, the positive rate gradually increased, the difference was significant (χ2 = 16.3, P <0.05) ; nm23 was negatively correlated with pathological grade (P <0.01). The positive expression rate of nm23 in non-lymph node metastasis was significantly higher than that of lymph node metastasis (71.9% and 20.0%, P <0.05). The expression of c-erbB-2 was correlated with the degree of differentiation and clinical stage of cancer cells, with high differentiation and strong expression of c-erbB-2 in early stage of cancer. Conclusion: The detection of p5 3, nm23 and c-erbB - 2 protein in endometrial carcinoma is helpful to predict the occurrence, progression, metastasis and prognosis of endometrial carcinoma.