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我院自1975年以来,对碳酸氢钠注射液中充二氧化碳的方法进行了研究,最后采用密闭加压充气法经三年多实践证明:比常温、常压、敞开的容器状况下充二氧化碳的成品合格率提高10％以上,现介绍如下:一、改进原理碳酸氢钠是个不稳定物质,60℃开始分解,2 NaHCO_3→Na_2CO_3+CO_2+H_2O,pH值升高,中国药典规定,碳酸氢钠注射液pH值应在8.6以下,为达到这个规定,一般用充二氧化碳的方法来控制,在实践中发
In our hospital since 1975, sodium bicarbonate injection of carbon dioxide in the study of the method, the last use of closed pressurized inflation method after more than three years of proven: than normal temperature and pressure, open the container under the conditions of filling carbon dioxide The qualification rate of the finished product is increased by over 10% as follows: First, the principle of improvement Sodium bicarbonate is an unstable substance that begins to decompose at 60 ° C, and the pH value of 2 NaHCO 3 → Na 2 CO 3 + CO 2 + H 2 O increases. The Chinese Pharmacopoeia states that sodium bicarbonate Injection pH should be 8.6 or less, in order to achieve this regulation, the general method of carbon dioxide control, in practice hair