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目的:探讨2型糖尿病与空腹血清游离脂肪酸的相关性。方法:随机取样患有糖尿病100例为此次研究对象,男25例,女25例,为观察组;男30例,女20例,为对照组。年龄为24-50岁,平均年龄为(30.5±5.66)岁。两组患者在性别、年龄、病情轻重等方面具有可比性。结果:观察组游离脂肪酸为0.99±0.25,胰岛素抵抗水平为5.01±3.10,胰岛素敏感性为64.25±11.30,对照组游离脂肪酸为0.55±0.35,胰岛素抵抗水平为3.35±2.11胰岛素敏感性为108.25±30.30。观察组空腹时游离脂肪酸高于对照组;观察组胰岛素抵抗水平高于对照组;观察组胰岛素敏感性低于对照组;观察组的糖尿病患者要少于对照组患者。结论:患者游离脂肪酸过多时,就会引发患者机体内的氧化应激,导致细胞发生氧化应激,造成机体内细胞和氧化应激损伤,致使患者血糖升高,出现糖尿病症状,胰岛素抵抗水平下降和胰岛素敏感性上升会间接形成2型糖尿病。空腹血清游离脂肪酸与机体内胰岛素抵抗水平以及2型糖尿病发展之间具有一定相关性,可以作为临床判断患者是否患有糖尿病的诊断指标。
Objective: To investigate the correlation between type 2 diabetes and fasting serum free fatty acid. Methods: A total of 100 cases of diabetes mellitus were randomized in this study. There were 25 males and 25 females, which were observation group. There were 30 males and 20 females as control group. Aged 24-50 years old, the average age was (30.5 ± 5.66) years old. Two groups of patients in gender, age, severity and other aspects comparable. Results: In the observation group, the free fatty acid was 0.99 ± 0.25, the insulin resistance was 5.01 ± 3.10, the insulin sensitivity was 64.25 ± 11.30, the control group was 0.55 ± 0.35, the insulin resistance was 3.35 ± 2.11, the insulin sensitivity was 108.25 ± 30.30 . The fasting fatty acid in the observation group was higher than that in the control group. Insulin resistance in the observation group was higher than that in the control group. Insulin sensitivity in the observation group was lower than that in the control group. Diabetic patients in the observation group were less than those in the control group. Conclusion: Patients with excessive free fatty acids, it will trigger the body’s oxidative stress in patients with lead to oxidative stress in cells, causing damage to cells and oxidative stress in the body, resulting in elevated blood glucose, symptoms of diabetes, decreased levels of insulin resistance And insulin sensitivity will indirectly lead to type 2 diabetes. Fasting serum free fatty acids and the level of insulin resistance in vivo and the development of type 2 diabetes have a certain correlation between, can be used as a clinical judgment of whether patients with diabetes diagnosis.